Document Detail


Changing ultrastructures in the estrous cycle and postnatal development of prolactin cells in the rat anterior pituitary as studied by immunogold electron microscopy.
MedLine Citation:
PMID:  3439846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three types of prolactin (PRL) cells of the rat anterior pituitary were recognized by immunogold electron microscopy: Type I cells are characterized by irregularly shaped large secretory granules (500 nm in maximum diameter); Type II cells contain spherical granules of varying size (150-250 nm); and Type III cells are immature forms with a narrow cytoplasm and small round granules (100 nm). In the male adult pituitary, Type II cells occur most frequently (48%), Type I cells slightly less frequently (46%), while Type III cells are very rare (6%). In the female gland, Type I cells exceed 90% of the total PRL cells, Type II cells make up 7% and Type III cells comprise 3% through the 4 day estrous cycle. Type I cells undergo marked changes in ultrastructure during the estrous cycle. This cell type shows ultrastructural signs of elevated secretory activity during the proestrus and estrus. The postnatal development of PRL cells was also studied. At 8 days after birth, immunoreactive PRL cells are mostly Type III cells (more than 80%), Type II cells are much fewer (17%), and no Type I cells can be observed. At 21 days the female pituitary fully matures with regard to PRL cells. From the 33rd day, the male PRL cells show characteristics of the male pituitary. Transitional features changing from Type III into Type II or from Type II into Type I were observed. It is thus suggested that Type III cells are primitive immature cells which may give rise to mature, functionally active Type II or Type I cells. The Type III cells may frequently undergo mitosis.
Authors:
K Kurosumi; S Tanaka; H Tosaka
Related Documents :
660666 - Replacement of serum in cell culture by hormones: a study of hormonal regulation of cel...
3100286 - Functional variations among prolactin cells from different pituitary regions.
17003256 - Involvement of calpain and synaptotagmin ca2+ sensors in hormone secretion from excitab...
3821376 - Effects of diazepam on cell proliferation in cerebral cortex, anterior pituitary and th...
19607906 - Antiproliferative effects of selenium compounds in colon cancer cells: comparison of di...
21908486 - Honokiol, a chemopreventive agent against skin cancer, induces cell cycle arrest and ap...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivum histologicum Japonicum = Nihon soshikigaku kiroku     Volume:  50     ISSN:  0004-0681     ISO Abbreviation:  Arch Histol Jpn     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2011-07-29    
Medline Journal Info:
Nlm Unique ID:  0146564     Medline TA:  Arch Histol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  455-78     Citation Subset:  IM    
Affiliation:
Department of Morphology, Gunma University, Maebashi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Estrus*
Female
Immunohistochemistry
Male
Microscopy, Electron
Pituitary Gland, Anterior / growth & development,  secretion,  ultrastructure*
Prolactin / analysis,  secretion*
Rats
Rats, Inbred Strains
Sex Characteristics*
Chemical
Reg. No./Substance:
9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The distribution and surface ultrastructure of airway epithelial cells in the rat lung: a scanning e...
Next Document:  The fine structure of the node of Ranvier in the rat cerebellar cortex.