| Changing trends in pregnancy outcome among HIV-infected women between 1985 and 1997 in two southern French university hospitals. | |
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MedLine Citation:
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PMID: 12206924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To analyze risk factors for pregnancy outcome among HIV-infected women before and after introduction of AZT prophylaxis in 1994. STUDY DESIGN: A prospective, two-center observational study conducted from 1 January 1985 to 31 December 1997. PATIENTS: Pregnant HIV-infected women followed in one of the obstetrics units during the study period. MAIN OUTCOME MEASURES: pregnancy outcome (normal delivery, ectopic pregnancy, spontaneous abortion, voluntary termination of pregnancy (TOP) according to year of pregnancy, age at pregnancy professional status, marital status, ethnic origin, mode of contamination, stage of disease, partner's human immunodeficiency virus (HIV) status and prior pregnancy. RESULTS: One thousand one hundred and three pregnancies among 937 HIV-infected women were studied. Mean age of patients was 28.1 +/- 4.9 years. Pregnancy outcomes were distributed as follows: 473 normal deliveries, 589 TOP, 9 ectopic pregnancies and 32 spontaneous abortions. The proportion of TOP decreased from 59.4% before 1994 to 37.5% from 1994 (P < 0.001). In univariate analysis, mode of transmission, marital status, ethnic origin, partner's HIV status and prior pregnancy were also significantly correlated with pregnancy outcome. However, after adjustment by logistic regression for each period (before and after 1994), mode of transmission no longer appeared to influence pregnancy outcome. CONCLUSION: Effective prevention of mother-to-child transmission of HIV infection appears to have influenced HIV-infected women's decisions on continuing their pregnancy to term. Incidence of voluntary TOP has decreased significantly after introduction of AZT. |
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Authors:
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A Bongain; A Berrebi; E Mariné-Barjoan; B Dunais; M Thene; C Pradier; J Y Gillet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 104 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-03 Completed Date: 2003-03-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 124-8 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
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Service de Gynécologie-Obstétrique, Reproduction et Médecine Foetale, CHU de Nice-Sophia Antipolis, Hôpital de l'Archet 2, 151, route de Saint-Antoine de Ginestière, BP 3079, 06202 Nice Cedex 3, France. abongain@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced
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statistics & numerical data Abortion, Spontaneous / epidemiology Adult Analysis of Variance Delivery, Obstetric Ethnic Groups Female France / epidemiology HIV Infections / epidemiology*, transmission HIV Seropositivity / epidemiology Humans Marital Status Parity Pregnancy Pregnancy Complications, Infectious / virology* Pregnancy Outcome* Pregnancy, Ectopic / epidemiology Prospective Studies Sexual Partners |
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