Document Detail

Changing trends in gestational trophoblastic disease.
MedLine Citation:
PMID:  17086806     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The New Mexico Tumor Registry (NMTR) and Surveillance, Epidemiology and End Results (SEER) registries were utilized to determine (30+)-year trends in gestational trophoblastic disease and choriocarcinoma. STUDY DESIGN: Age-adjusted incidence rates of gestational trophoblastic disease per 100,000 woman-years (1973-2003) and ratios per live births and pregnancies were calculated using data abstracted from the NMTR and state vital records. SEER data (1973-2002) were used to calculate age-adjusted incidence rates, estimated annual percentage change (EAPC) and relative survival rates for choriocarcinoma. RESULTS: In New Mexico there were 1,153 cases affecting 377 non-Hispanic whites, 504 Hispanics and 241 American Indians, with respective incidence rates of 3.494, 5.150 and 9.991 (p < 0.0001). American Indian incidence rates decreased 53.3%, from 13.34 (1988-1992) to 6.23 (1998-2002). Within SEER (1973-2002), there were 504 gestational choriocarcinomas. The 30-year incidence rate was 0.132 and decreased by 37.7% (EAPC, -2.1% per year; p=0.0001)-by 40.1% for whites, 55.9% for blacks and 62.1% for others. However, over the previous 10 years, rates among blacks (0.097 vs. 0.259, p = 0.01) and for distant disease (0.044 vs. 0.071, p = 0.046) increased. CONCLUSION: Disparities in incidence rates by race/ethnicity in New Mexico are decreasing. An increase in rates among blacks and distant disease diagnosis may be the consequence of fewer regional trophoblastic centers in the United States.
Harriet O Smith; Charles Wiggins; Claire F Verschraegen; Laurence W Cole; Heather M Greene; Carolyn Y Muller; Clifford R Qualls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  51     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-01-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-84     Citation Subset:  IM    
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-5286, USA.
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MeSH Terms
Age Factors
Disease-Free Survival
Ethnic Groups / statistics & numerical data
Gestational Trophoblastic Neoplasms / epidemiology*,  ethnology,  etiology,  mortality
Health Transition
Maternal Health Services
Maternal Mortality / trends
Middle Aged
New Mexico / epidemiology
Population Surveillance
SEER Program
Survival Analysis
Uterine Neoplasms / epidemiology*,  ethnology,  etiology,  mortality
Grant Support
N01-67007//PHS HHS

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