Document Detail


Changing trends in the UK management of childhood ITP.
MedLine Citation:
PMID:  22039183     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ObjectiveTo compare the treatment of childhood immune thrombocytopenia (ITP) with historical practice in the UK.DesignData collection through a national UK Childhood ITP registry (http://www.uk-itp.org) started in January 2007.SettingsUK hospitals.ParticipantsChildren admitted with a new diagnosis of acute ITP and their treating physicians.Main outcome measuresBleeding severity, platelet count, disease management and outcome from the time of presentation to 6 months.ResultsData from 225 children were analysed. 54% of children had clinically mild, 42% had moderate and 4% had severe disease as defined previously.1 The mean platelet counts at diagnosis for these groups were 14, 8 and 6×10(9)/l respectively. Children with mild disease had fewer bleeding sites (1.9), compared with moderate (2.5) or severe disease (3.6). There was one intracranial haemorrhage reported. At 6 months' follow-up, 32% had a persistent platelet count <150×10(9)/l, but only 4.8% had a count <20. The proportion of UK children receiving platelet-raising treatment was noted to decrease from 61% in 1995 to 38% in 2000. The current UK 2009 registry data show a continued decrease in treatment to 16% of all the children. In contrast, historical international data report 69% of children receiving interventional therapy.ConclusionThe current UK practice has shown a continued reduction in the number of children receiving treatment in comparison with historical data and international practice.
Authors:
John D Grainger; Joanne L Rees; Marie Reeves; Paula H B Bolton-Maggs
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-28
Journal Detail:
Title:  Archives of disease in childhood     Volume:  -     ISSN:  1468-2044     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The University of Manchester, Manchester Academic Health Science Centre, Royal Manchester Children's Hospital, Manchester, UK.
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