| Changing patterns of medication use in patients with rheumatoid arthritis in a Medicaid population. | |
| | |
MedLine Citation:
|
PMID: 18499716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine changes in patterns of medication utilization in patients with RA. METHODS: Data from Tennessee Medicaid (TennCare) databases (1995-2004) were used to identify adults with both a diagnosis of RA and at least one DMARD prescription each year. Annual age-specific utilization of DMARDs, glucocorticoids, NSAIDs and narcotics was measured on the last day of each year to determine the point prevalence of use of these agents. RESULTS: Records from 23 342 patients with treated RA were analysed. Most patients were females (78%) and white (74%). The median age was 57 yrs (interquartile range: 48-65). The proportion of patients who had a current DMARD prescription on the index date increased from 62% in 1995 to 71% in 2004 (P < 0.001). MTX was the most commonly used DMARD. By the end of 2004, 22% of patients had a current prescription for a biologic, and etanercept represented 51% of all biologic therapies. During the study period, the overall utilization of glucocorticoids decreased from 46% to 38% (P < 0.001), whereas NSAID utilization increased from 33% to 38% (P < 0.001), and use of narcotics increased from 38% to 55% (P < 0.001). A secondary analysis that identified RA patients based on diagnosis codes alone, showed similar patterns, but lower DMARD utilization which increased from 33% to 52% overall and from 0% to 16% for biologics. CONCLUSIONS: The utilization of DMARDs increased in TennCare patients with RA, and by 2004, use of biologics was substantial. Although glucocorticoid utilization decreased, use of both NSAIDs and narcotics increased. |
| | |
Authors:
|
C G Grijalva; C P Chung; C M Stein; E F Mitchel; M R Griffin |
Related Documents
:
|
9546236 - Genetic risk factor for abdominal aortic aneurysm: hla-dr2(15), a japanese study. 18276936 - Keitel functional test for patients with rheumatoid arthritis: translation, reliability... 2487716 - Self-report questionnaires in five rheumatic diseases: comparisons of health status con... 8782146 - Non-hodgkin's lymphoma in patients with rheumatoid arthritis treated with low dose meth... 3243266 - Self-induction of seizures: the ultimate non-compliance. 15354406 - Systemic and haemodynamic toxicity after isolated limb perfusion (ilp) with tnf-alpha. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2008-05-22 |
Journal Detail:
|
Title: Rheumatology (Oxford, England) Volume: 47 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-06-18 Completed Date: 2008-07-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
|
Languages: eng Pagination: 1061-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Preventive Medicine, Vanderbilt University School of Medicine, 1500 21st Avenue, 2600 VAV, Nashville, TN 37212, USA. carlos.grijalva@vanderbilt.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Analgesics, Opioid / therapeutic use Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Antirheumatic Agents / therapeutic use* Arthritis, Rheumatoid / drug therapy*, epidemiology Drug Therapy, Combination Drug Utilization / statistics & numerical data, trends Female Glucocorticoids / therapeutic use Humans Immunologic Factors / therapeutic use Male Medicaid / statistics & numerical data, trends* Middle Aged Tennessee / epidemiology United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
|
290200500421//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antirheumatic Agents; 0/Glucocorticoids; 0/Immunologic Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-RNA polymerase III antibodies in patients with systemic sclerosis detected by indirect immunofl...
Next Document: Ankle-brachial pressure index: a simple tool for assessing cardiovascular risk in patients with syst...