Document Detail

Changing patterns of bleeding in patients with severe haemophilia A.
MedLine Citation:
PMID:  19659938     Owner:  NLM     Status:  MEDLINE    
Previous studies on the pattern of joint bleeding in patients with haemophilia have reported that the knee joint is most frequently affected. Home treatment data reporting bleeding frequency and location collected from 100 patients registered at six haemophilia centres in the UK have been analysed to determine current patterns of bleeding. Bleeding frequency has markedly decreased although bleeding into joints remains the main characteristic of haemophilia. However, the ankle joint has replaced the knee joint as the most common joint affected. Furthermore, it seems that the frequency of knee joint bleeding is also less than the elbow joint suggesting that the traditional pattern of joint bleeding in haemophilia has now changed significantly.
D Stephensen; R C Tait; N Brodie; P Collins; R Cheal; D Keeling; K Melton; G Dolan; H Haye; E Hayman; M Winter
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-07-29
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  15     ISSN:  1365-2516     ISO Abbreviation:  Haemophilia     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-11     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1210-4     Citation Subset:  IM    
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, UK.
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MeSH Terms
Age Factors
Ankle Joint / physiology*
Elbow Joint / physiology*
Factor VIII / therapeutic use
Hemarthrosis / complications*,  epidemiology,  physiopathology
Hemophilia A / complications*,  epidemiology,  physiopathology
Knee Joint / physiology*
Range of Motion, Articular / physiology
Retrospective Studies
Self Care
Weight-Bearing / physiology*
Young Adult
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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