Document Detail

Changing patterns of antiepileptic drug use in pregnant Australian women.
MedLine Citation:
PMID:  20015108     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To trace the pattern of antiepileptic drug (AED) use in pregnant Australian women annually from 1999 to 2007, and correlate it with the pattern of AED use in the wider community. METHODS: Analysis of data from the Australian Register of AEDs in Pregnancy, related to Australian population data for AED prescriptions. RESULTS: Over the study period, prescribing of carbamazepine, phenytoin and valproate for pregnant women decreased, and prescribing of lamotrigine, topiramate and levetiracetam increased. These changes tended to parallel prescribing trends in the wider community, except for valproate, whose prescribing in the overall community increased as its prescribing, and its dosage prescribed, decreased in pregnancy. Concomitant with this, there was a trend towards fewer births of foetuses with abnormalities. CONCLUSIONS: While otherwise following national AED prescribing trends, Australian prescribers are reducing the use and dose of valproate in pregnant women, likely in recognition of the teratogenic hazards of this drug.
F J E Vajda; S Hollingworth; J Graham; A A Hitchcock; T J O'Brien; C M Lander; M J Eadie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-15
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  121     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Department of Medicine and Neurosciences, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
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MeSH Terms
Anticonvulsants / administration & dosage,  adverse effects,  therapeutic use*
Congenital Abnormalities
Epilepsy / drug therapy*
Linear Models
Physician's Practice Patterns / trends*
Pregnancy Complications / drug therapy*
Valproic Acid / administration & dosage,  adverse effects,  therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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