Document Detail

Changing patterns of Hodgkin lymphoma incidence in Singapore.
MedLine Citation:
PMID:  18470916     Owner:  NLM     Status:  MEDLINE    
A bimodal age-specific incidence pattern with a relatively high proportion of cases occurring in adolescents and young adults is a hallmark of Hodgkin lymphoma (HL) epidemiology in Western industrialized countries. The young adult incidence peak is believed to reflect the association between HL risk in young adults and an affluent childhood socioeconomic environment. However, the dynamic development of the young adult incidence peak following socioeconomic development implied by this interpretation has scarcely been demonstrated in a single population over time. We, therefore, analyzed incidence patterns of HL in Singapore between 1968 and 2004, during which time period a socioeconomic transition towards Western World lifestyles took place. As hypothesized a HL incidence peak emerged among adolescents and young adults in Singapore. Thus, in the age groups 15-19 and 20-24 years incidence rates increased annually by 7.0% (95% confidence interval 3.4%-10.7%) and 3.4% (0.1%-6.8%), respectively, in men and by 13.7% (9.1%-18.6%) and 12.2% (7.8-16.8%), respectively, in women between 1968 and 2004. However, the incidence peak remained considerably lower than what can be observed in young adults in the Western World. It remains to be determined to what extent the current lower incidence of HL in young Asian adults should be attributed to birth cohort phenomena, as would be suggested by continued increase in incidence, and to ethnic variation in HL susceptibility between Asian and non-Asian populations, respectively.
Henrik Hjalgrim; Adeline Seow; Klaus Rostgaard; Jeppe Friborg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  123     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-9     Citation Subset:  IM    
Department of Epidemiology Research, Statens Serum Institut, Denmark.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Confidence Intervals
Genetic Predisposition to Disease
Hodgkin Disease / epidemiology*,  ethnology
Middle Aged
Poisson Distribution
Singapore / epidemiology
Socioeconomic Factors

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