| Changing patterns of Hodgkin lymphoma incidence in Singapore. | |
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MedLine Citation:
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PMID: 18470916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A bimodal age-specific incidence pattern with a relatively high proportion of cases occurring in adolescents and young adults is a hallmark of Hodgkin lymphoma (HL) epidemiology in Western industrialized countries. The young adult incidence peak is believed to reflect the association between HL risk in young adults and an affluent childhood socioeconomic environment. However, the dynamic development of the young adult incidence peak following socioeconomic development implied by this interpretation has scarcely been demonstrated in a single population over time. We, therefore, analyzed incidence patterns of HL in Singapore between 1968 and 2004, during which time period a socioeconomic transition towards Western World lifestyles took place. As hypothesized a HL incidence peak emerged among adolescents and young adults in Singapore. Thus, in the age groups 15-19 and 20-24 years incidence rates increased annually by 7.0% (95% confidence interval 3.4%-10.7%) and 3.4% (0.1%-6.8%), respectively, in men and by 13.7% (9.1%-18.6%) and 12.2% (7.8-16.8%), respectively, in women between 1968 and 2004. However, the incidence peak remained considerably lower than what can be observed in young adults in the Western World. It remains to be determined to what extent the current lower incidence of HL in young Asian adults should be attributed to birth cohort phenomena, as would be suggested by continued increase in incidence, and to ethnic variation in HL susceptibility between Asian and non-Asian populations, respectively. |
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Authors:
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Henrik Hjalgrim; Adeline Seow; Klaus Rostgaard; Jeppe Friborg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 123 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-06-03 Completed Date: 2008-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 716-9 Citation Subset: IM |
Affiliation:
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Department of Epidemiology Research, Statens Serum Institut, Denmark. hhj@ssi.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Confidence Intervals Female Genetic Predisposition to Disease Hodgkin Disease / epidemiology*, ethnology Humans Incidence Infant Male Middle Aged Poisson Distribution Singapore / epidemiology Socioeconomic Factors |
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