Document Detail

Changing pattern of perinatal brain injury in term infants in recent years.
MedLine Citation:
PMID:  22264705     Owner:  NLM     Status:  In-Data-Review    
Perinatal brain injury in term infants remains a significant clinical problem. Recently a change appears to have occurred in the pattern of such injuries. We sought to characterize the incidence, etiology, clinical manifestations, and outcomes of these injuries. A retrospective chart review identified clinical characteristics of neuroimaging, electroencephalography, and placental pathologic findings. Perinatal depression was defined as hypotonia and the need for respiratory support. From January 2004-December 2009, 29,597 term deliveries occurred. Brain injuries in 33 infants (live term births) included hypoxic-ischemic encephalopathy (n = 8; 0.27/1000), subdural hemorrhage (n = 10; 0.34/1000), intraventricular/intraparenchymal hemorrhage (n = 5; 0.17/1000), and focal cerebral infarctions (n = 4; 0.14/1000). Thirteen of 33 infants (39%) were triaged to a regular nursery. Delayed presentations included apnea (n = 6), desaturation episodes (n = 3), and seizures (n = 4). Twenty of 33 (61%) were admitted directly to the neonatal intensive care unit because of perinatal depression or evolving hypoxic-ischemic encephalopathy. Clinical signs included seizures (n = 12) and apnea (n = 2). Nine of 19 manifested electroencephalographic seizures. Pathology included chorioamnionitis (n = 7) and fetal thrombotic vasculopathy (n = 5). The latter was associated with focal cerebral infarctions in 3/4 cases. Most cases attributable to perinatal brain injury, except for evolving hypoxic-ischemic encephalopathy, are not identified according to any perinatal characteristics until the onset of signs, limiting opportunities for prevention.
Toshiki Takenouchi; Ericalyn Kasdorf; Murray Engel; Amos Grunebaum; Jeffrey M Perlman
Related Documents :
15823935 - Reduced litter sizes following 48-h of prenatal exposure to 5 nt to 10 nt,0.5 hz magnet...
8404975 - An assessment of the microsocial environment of children diagnosed as "sudden infant de...
525245 - Vibrissae removal and the phenomenon of unexplained sudden death.
9146135 - Sudden death and the theatre nurse.
19397555 - Ultrasonography as predictor of permanent renal damage in infants with urinary tract in...
2029275 - Pneumograms in premature infants: a study of longitudinal data.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  46     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Division of Pediatric Neurology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations.
Next Document:  Neonatal seizures: treatment practices among term and preterm infants.