| Changing gears in the cell cycle: histoblasts and beyond. | |
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MedLine Citation:
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PMID: 19934653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the molecular elements controlling cell cycle progression are well established, the mechanisms regulating how cell proliferation is triggered in response to extrinsic stimuli and how cell divisions change speed, particularly in stem or tumor cells or regenerative tissues, are poorly understood. One exceptional model system in which these events are precisely defined is Drosophila abdominal morphogenesis, in which stem-like histoblasts build the adult epidermis at metamorphosis by undergoing a series of sequential transitions from a non-proliferative to a growing, and finally to an invasive epithelium. We have recently uncovered in histoblasts an internal logic modulating cell cycle transitions that should constitute a reference paradigm for the study of other equivalent processes in stem cell, cancer or developmental biology. |
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Authors:
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Nikolay Ninov; Enrique Mart?n-Blanco |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-27 |
Journal Detail:
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Title: Fly Volume: 3 ISSN: 1933-6942 ISO Abbreviation: Fly (Austin) Publication Date: 2009 Oct-Nov |
Date Detail:
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Created Date: 2009-12-21 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101470897 Medline TA: Fly (Austin) Country: United States |
Other Details:
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Languages: eng Pagination: 286-9 Citation Subset: IM |
Affiliation:
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Instituto de Biolog?a Molecular de Barcelona, Consejo Superior de Investigaciones Cient?ficas, Parc Cientific de Barcelona, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Abdomen / growth & development* Animals Cell Cycle / physiology* Cell Differentiation / physiology* Cell Proliferation Drosophila Drosophila Proteins / metabolism Epithelium / growth & development* Metamorphosis, Biological / physiology* Models, Biological Morphogenesis / physiology* Receptor, Epidermal Growth Factor / metabolism Receptors, Invertebrate Peptide / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Receptors, Invertebrate Peptide; EC 2.7.1.112/Egfr protein, Drosophila; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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