Document Detail

Changing dopaminergic activity through different pathways: consequences for renal sodium excretion, regional blood flow and oxygen tension in the rat.
MedLine Citation:
PMID:  11472309     Owner:  NLM     Status:  MEDLINE    
Dopamine (DA) is an intrarenal natriuretic hormone involved in sodium homeostasis, but the regulation of renal dopaminergic tonus is unclear. We evaluated different pathways for elevating DA tonus to determine which are important for the ability of the kidney to produce natriuresis and studied the accompanying effects on regional renal blood flow and oxygen tension. Thus, we compared the effects of a catechol-O-methyl transferase (COMT)-inhibitor, an unspecific monoamine oxidase (MAO)-inhibitor, a D1-like receptor agonist and a DA precursor in anaesthetized rats. Sodium excretion increased sixfold after COMT inhibition, eightfold after administration of the D1-like agonist, whereas it was similar to control after MAO inhibition and infusion of DA precursor. Urinary dopamine excretion increased 42% by COMT inhibition, 55% by MAO inhibition and 12-fold after DA precursor, but remained unchanged after infusion of the D1-like agonist. The D1-like receptor agonist led to a 38% increase in the cortical blood flow and a 21% increase in outer medullary blood flow. Regional renal blood flow was unaffected by all other treatments. Cortical and outer medullary oxygen tension was unaffected in all treatment groups. To conclude, the natriuretic and haemodynamic properties of an elevation in DA tonus depends on the route by which the elevation occurred. Systemic administration of a D1-like receptor agonist, results in a natriuretic response which, as opposed to the natriuresis seen after COMT inhibition, coincides with an increase in renal cortical and outer medullary blood flow. Precursor delivery or MAO inhibition did not change neither urinary sodium excretion nor renal blood flow.
C Odlind; A Fasching; P Liss; F Palm; P Hansell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  172     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-26     Completed Date:  2001-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Department of Physiology, Biomedical Centre, University of Uppsala, Uppsala, Sweden.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / urine
Blood Pressure / physiology
Catechol O-Methyltransferase / metabolism
Dopamine / physiology*
Kidney / metabolism*
Oxygen / blood*
Oxygen Consumption / physiology
Rats, Sprague-Dawley
Regional Blood Flow / physiology
Renal Circulation / physiology*
Sodium / urine*
Sodium-Hydrogen Antiporter / metabolism
Sodium-Potassium-Exchanging ATPase / metabolism
Reg. No./Substance:
0/Sodium-Hydrogen Antiporter; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 7440-23-5/Sodium; 7782-44-7/Oxygen; EC O-Methyltransferase; EC ATPase

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