| Changing distribution of cadherins during gestation in the uterine epithelium of lizards. | |
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MedLine Citation:
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PMID: 21612011 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The uterine epithelium provides the interface between an embryo and its mother during pregnancy. Calcium-dependent cadherins are adherens junction proteins that undergo major shifts in the uterine epithelium to facilitate the communication between maternal cells and the embryonic milieu during implantation in mammals. They are, therefore, important in trophoblast invasion and the maintenance of pregnancy. We investigated spatiotemporal changes of cadherins throughout pregnancy in the uterine epithelium of two viviparous skinks and one oviparous population, which all exhibit a noninvasive (epitheliochorial) placenta. Cadherins were identified for the first time in squamate reptiles. In all species, cadherins are reduced in the uterine epithelium as gestation progresses, which would lessen the attachment between uterine epithelial cells and allow them to stretch to accommodate embryonic growth. Interestingly, cadherins were reduced sooner after ovulation in the oviparous species than in the viviparous species. In viviparous species, the different expression of cadherins between barren and pregnant uteri from the same mother indicates that expression of cadherins may not be driven solely by maternal hormones, but also by the presence of an embryo. The redistribution of cadherins in squamates is comparable to that of mammals, reflecting establishment of feto-maternal communication during the peri-implantation period. As there is no breaching of maternal tissue in lizards, the change in adherens junctional properties are thus not exclusive to mammals with invasive placentae, which suggests that similar molecular mechanisms regulate changes to uterine epithelia during pregnancy across placental types. J. Exp. Zool. (Mol. Dev. Evol.) 314B, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Qiong Wu; Michael B Thompson; Christopher R Murphy |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-24 |
Journal Detail:
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Title: Journal of experimental zoology. Part B, Molecular and developmental evolution Volume: - ISSN: 1552-5015 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168228 Medline TA: J Exp Zool B Mol Dev Evol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc., A Wiley Company. |
Affiliation:
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School of Biological Sciences, The University of Sydney, Sydney, NSW, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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