| Changing concepts of cerebrospinal fluid hydrodynamics: role of phase-contrast magnetic resonance imaging and implications for cerebral microvascular disease. | |
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MedLine Citation:
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PMID: 17599715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phase-contrast magnetic resonance imaging (PC-MRI) or flow-sensitive MRI can be used to noninvasively measure intracranial vascular and CSF flow. Monro-Kellie homeostasis is the complex compensatory mechanism for the increase in intracranial blood volume during systole. Through PC-MRI techniques, our understanding of Monro-Kellie homeostasis and the associated intracranial hydrodynamics has greatly improved. Failure of this homeostatic mechanism has been implicated in a wide range of cerebral disorders, including vascular and Alzheimer's dementia, late-onset depression, benign and secondary intracranial hypertension, communicating and normal pressure hydrocephalus, and age-related white matter changes. The most common mode of homeostatic failure is due to vascular disease with decreased cerebral arterial compliance. This has wide-reaching implications in the investigation of patients with cerebral vascular disease. Here we discuss the role of PC-MRI in the study of cerebral hydrodynamics and the current understanding of Monro-Kellie homeostasis in both healthy and disease states. Quantitative assessment of the changes in this homeostatic mechanism using PC-MRI has important implications in the development of biomarkers of vascular involvement in disease with application in diagnosis, treatment planning, phenotype identification, and outcome assessment in clinical trials. |
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Authors:
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Stavros Michael Stivaros; Alan Jackson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Volume: 4 ISSN: 1933-7213 ISO Abbreviation: - Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-29 Completed Date: 2007-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101290381 Medline TA: Neurotherapeutics Country: United States |
Other Details:
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Languages: eng Pagination: 511-22 Citation Subset: IM |
Affiliation:
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Imaging Science and Biomedical Engineering, The Medical School, University of Manchester, Manchester, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / physiology* Cerebrospinal Fluid / physiology* Cerebrovascular Disorders / physiopathology* Homeostasis Humans Magnetic Resonance Imaging* |
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