Document Detail

Changing clinical presentations and survival pattern in trisomy 18.
MedLine Citation:
PMID:  19750888     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The clinical presentations and survival patterns of infants with trisomy 18 have changed with increasing utilization of prenatal ultrasound and amniocentesis, and improvements in neonatal intensive care. METHODS: We obtained data on duration of survival, male to female ratio, and clinical details for patients with trisomy 18, and calculated the prevalence rate. RESULTS: We studied 31 consecutive trisomy 18 infants. The estimated prevalence was 1/4, 144. Eleven (35%) were premature infants, and 20 (65%) were full term. Mean birth weight was 1896 g. Median life expectancy was 12 days; 11 days for males and 14 days for females (p = 0.87). The short-term survival rates of 1 week, 4 weeks, and 6 months were 58%, 32%, and 10%, respectively. The long-term survival rates of 1 year, 2 years, and 3 years were 6%, 6%, and 3%, respectively. Families signed do-not-resuscitate consent forms for five male (50%) and 19 female infants (90%) (p = 0.043). CONCLUSION: All trisomy 18 infants in this study were preterm or full-term deliveries. Mean birth weight was lower than previously reported, and a high percentage of families signed do-not-resuscitate consent forms. Females did not survive longer than males, due to more females not being resuscitated. Most infants died in the first few weeks of life, but 3-6% of infants lived for 21 year. The possibility of long-term survival should be considered when counseling parents regarding trisomy 18.
Chien-Chou Hsiao; Lon-Yen Tsao; Hsiao-Neng Chen; Han-Yao Chiu; Weng-Cheng Chang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  50     ISSN:  1875-9572     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-15     Completed Date:  2009-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital, Changhua Christian Hospital, Taiwan.
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MeSH Terms
Abnormalities, Multiple / genetics,  mortality,  pathology
Chromosome Disorders / diagnosis,  mortality*
Chromosomes, Human, Pair 18*
Infant, Newborn
Survival Rate
Comment In:
Pediatr Neonatol. 2009 Aug;50(4):133-4   [PMID:  19750885 ]

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