Document Detail

Changing annual incidence of hypothyroidism after iodine-131 therapy for hyperthyroidism, 1951-1975.
MedLine Citation:
PMID:  7057249     Owner:  NLM     Status:  MEDLINE    
The incidence of hypothyroidism was analyzed in 4,553 hyperthyroid patients treated with I-131 between 1951 and 1975. The average annual rate of hypothyroidism during the first 7 yr after therapy increased continuously for each 5-yr period of treatment, from 3.6% for patients treated between 1951 and 1955 to 7.7% for patients treated during the period from 1971 though 1975 (p less than 0.001). The increase in the incidence of hypothyroidism was seen before the introduction of TSH assays and when allowance was made for thyroid gland size, the age of the patient, and the experience of the radiotherapist. The use of TSH assays has probably resulted in an earlier recognition of hypothyroidism, which may explain why the most marked rise in the incidence of hypothyroidism was observed after the introduction of TSH assays.
L E Holm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  23     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  IM    
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MeSH Terms
Age Factors
Epidemiologic Methods
Follow-Up Studies
Hyperthyroidism / radiotherapy*
Hypothyroidism / blood,  etiology*
Iodine Radioisotopes / adverse effects*
Radiotherapy Dosage
Thyrotropin / blood
Time Factors
Reg. No./Substance:
0/Iodine Radioisotopes; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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