| Changing Views of the Role of Langerhans Cells. | |
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MedLine Citation:
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PMID: 22217741 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Langerhans cells (LCs) have long been considered to be the major sensitizing cells in the skin by initiating productive immunity in naive resting T cells. This picture has changed over the past decade. We now know (i) that the skin also harbors other types of dendritic antigen-presenting cells and (ii) that the genetically driven removal of the LC population results in increased T-cell immunity against haptens and infectious agents. It is not clear at present whether the situation in genetically modified mice is in any way indicative of the actual in vivo function of LCs. Exciting and challenging years lie ahead of the LC research community.Journal of Investigative Dermatology advance online publication, 5 January 2012; doi:10.1038/jid.2011.437. |
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Authors:
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Nikolaus Romani; Patrick M Brunner; Georg Stingl |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-05 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: - ISSN: 1523-1747 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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