Document Detail

Changes within vascular bundles of rodent kidneys caused by different diets.
MedLine Citation:
PMID:  880629     Owner:  NLM     Status:  MEDLINE    
Morphological effects caused by two different diets (low protein-high water intake, and high protein-restricted water) on the vascular bundles in the outer medullary zone of the kidney were studied in the laboratory white mouse and in the golden spiny mouse (Acomys russatus, Muridae). In both rodents, when on a low protein-high water intake diet, considerable interstitial substance was found between the vasa recta of the bundles. No interstitial substance was found in animals on high protein-low water intake diet; as a result the vasa recta of the vascular bundle adhered closely. The low protein-high water intake diet caused a marked diuresis, low urine osmolality and low urinary urea concentration. It is assumed that the increase in interstitial substance between the vasa recta of the vascular bundle lowers the efficiency of the counter current barrier system for urea in the kidney and, as a consequence, the medullary urea gradient and urine concentrating capacity decreases. In animals on a high protein diet, the closely juxtaposed vasa recta assure an efficient countercurrent exchange, leading to accumulation and maintenance of a large urea gradient in the medulla and maximal urine concentration. It is suggested that the amount of interstitial material between the vasa recta of the vascular bundle might serve as a modulating factor for the urea concentration in the kidney.
D Yaakobi; A Borut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell and tissue research     Volume:  181     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
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MeSH Terms
Animal Nutritional Physiological Phenomena*
Dietary Proteins
Kidney / blood supply*
Osmolar Concentration
Rodentia / anatomy & histology*
Urea / urine
Reg. No./Substance:
0/Dietary Proteins; 57-13-6/Urea; 7732-18-5/Water

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