| Changes of transmembrane Ca2+ gradient in the formation of macrophage-derived foam cells. | |
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MedLine Citation:
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PMID: 10888406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophages from C57BL/6J mice, an animal susceptible to atherosclerosis, were chosen as target cells to study changes in the transmembrane Ca2+ gradient during the formation of macrophage-derived foam cells. The transmembrane Ca2+ gradients of single living cells were examined-using Fura-2/AM combined with Fluo-3/AM by laser scanning confocal microscopy. Exposure to Oxidized Low Density Lipoprotein, decreases the Ca2+ gradient across macrophage plasma membrane, but increases that across the nuclear membrane. The altered transmembrane Ca2+ gradients could induce the up-regulation of scavenger receptor in macrophages, resulting in the formation of foam cells. |
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Authors:
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X Yang; Y Zhang; Y Huang; F Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioscience reports Volume: 20 ISSN: 0144-8463 ISO Abbreviation: Biosci. Rep. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-10-02 Completed Date: 2000-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102797 Medline TA: Biosci Rep Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
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NCI-FCRDC, Frederick, Maryland 21702, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism* Cell Membrane / metabolism Cell Nucleus / metabolism Cholesterol / blood Cytosol / metabolism Flow Cytometry Foam Cells / metabolism* Humans Ions Lipoproteins, LDL / blood, metabolism Macrophages / metabolism* Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Microscopy, Confocal Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Ions; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 57-88-5/Cholesterol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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