| Changes of some amino acid concentrations in the medial vestibular nucleus of conscious rats following acute hypotension. | |
| | |
MedLine Citation:
|
PMID: 20399837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Microdialysis and high performance liquid chromatography (HPLC) were used to measure the changes of certain amino acids in the medial vestibular nucleus (MVN) of conscious rats in order to understand whether those amino acids are involved in the regulation of blood pressure. Acute hypotension was induced by infusing sodium nitroprusside (SNP) into the femoral vein. In the control group, glutamate (Glu) release increased, though gamma-aminobutyric acid (GABA) and taurine (Tau) release decreased in the MVN following acute hypotension. In the unilateral labyrinthectomy group, the levels of Glu, GABA, and Tau were unchanged in the ipsilateral MVN to the lesion following acute hypotension. Furthermore, in the contralateral MVN to the lesion, Glu release increased, and GABA and Tau release decreased following acute hypotension. These results suggest that SNP-induced acute hypotension can influence the activity of neurons in the MVN through afferent signals from peripheral vestibular receptors, and that certain amino acid transmitters in the MVN are involved in this process. |
| | |
Authors:
|
Xiang-Lan Li; Ying An; Qing-Hua Jin; Min Sun Kim; Byung Rim Park; Yuan-Zhe Jin |
Related Documents
:
|
6106387 - The role of gamma-glutamyl transpeptidase in the nephrotoxicity of an agaricus bisporus... 12742517 - Potentiation of metabotropic gabab receptors by l-amino acids and dipeptides in rat neo... 10434007 - Role of nitric oxide on gaba, glutamic acid, activities of gaba-t and gad in rat brain ... 6366787 - Aminomalonic acid: identification in escherichia coli and atherosclerotic plaque. 4063307 - Digestion, absorption and utilization of single-cell protein by the preruminant calf. t... 9178187 - Characteristics of cefdinir uptake by rabbit small intestinal brush-border membrane ves... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
|
Title: Neuroscience letters Volume: 477 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-24 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
|
Languages: eng Pagination: 11-4 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Physiology and Pathophysiology, Yanbian University College of Basic Medicine and Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules (Yanbian University), Ministry of Education, 1829 Juzi Road, Yanji 133000, Jilin Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Animals Blood Pressure Chromatography, High Pressure Liquid Glutamic Acid / metabolism* Hypotension / metabolism*, physiopathology Male Microdialysis Rats Taurine / metabolism* Vestibular Nuclei / metabolism*, physiopathology gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
107-35-7/Taurine; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: POLG1 polyglutamine tract variants associated with Parkinson's disease.
Next Document: Multiple cognitive control mechanisms associated with the nature of conflict.