| Changes of placental Kiss-1 mRNA expression and maternal/cord kisspeptin levels at preterm delivery. | |
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MedLine Citation:
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PMID: 19017815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kisspeptin, a placental polypeptide secreted throughout pregnancy, is suggested to play a role at parturition. Here we evaluated whether its placental mRNA expression and maternal/fetal plasma levels change at term and preterm delivery, and its effect on oxytocin secretion from placental explants. Samples were collected from 40 women with singleton pregnancies who underwent elective cesarean section at term (TNL), term vaginal delivery (TD), and preterm vaginal delivery (PTD). Plasma Kisspeptin and oxytocin levels were assessed by ELISA; placental mRNA expression by Real-time quantitative RT-PCR analysis. Placental expression was significantly (P < 0.0001) higher in PTD than TNL and TD and significantly (P < 0.001) higher in TD than TNL. Maternal/fetal plasma concentrations did not differ among the groups, and maternal were significantly higher than fetal levels (P < 0.05). In placental explants increasing doses of kisspeptin did not modify oxytocin secretion. In conclusion, labor is associated with increased placental KiSS-1 expression without changes in maternal/fetal circulation. |
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Authors:
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Michela Torricelli; Letizia Galleri; Chiara Voltolini; Giulia Biliotti; Pasquale Florio; Maria De Bonis; Felice Petraglia |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 15 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 779-84 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight / physiology Female Fetal Blood / metabolism Gene Expression Regulation Humans Infant, Newborn Obstetric Labor, Premature / blood, metabolism* Oxytocin / secretion Placenta / metabolism, physiology* Pregnancy RNA, Messenger / biosynthesis, genetics Reverse Transcriptase Polymerase Chain Reaction Tumor Suppressor Proteins / biosynthesis*, blood, genetics |
| Chemical | |
Reg. No./Substance:
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0/KISS1 protein, human; 0/RNA, Messenger; 0/Tumor Suppressor Proteins; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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