Document Detail


Changes of placental Kiss-1 mRNA expression and maternal/cord kisspeptin levels at preterm delivery.
MedLine Citation:
PMID:  19017815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kisspeptin, a placental polypeptide secreted throughout pregnancy, is suggested to play a role at parturition. Here we evaluated whether its placental mRNA expression and maternal/fetal plasma levels change at term and preterm delivery, and its effect on oxytocin secretion from placental explants. Samples were collected from 40 women with singleton pregnancies who underwent elective cesarean section at term (TNL), term vaginal delivery (TD), and preterm vaginal delivery (PTD). Plasma Kisspeptin and oxytocin levels were assessed by ELISA; placental mRNA expression by Real-time quantitative RT-PCR analysis. Placental expression was significantly (P < 0.0001) higher in PTD than TNL and TD and significantly (P < 0.001) higher in TD than TNL. Maternal/fetal plasma concentrations did not differ among the groups, and maternal were significantly higher than fetal levels (P < 0.05). In placental explants increasing doses of kisspeptin did not modify oxytocin secretion. In conclusion, labor is associated with increased placental KiSS-1 expression without changes in maternal/fetal circulation.
Authors:
Michela Torricelli; Letizia Galleri; Chiara Voltolini; Giulia Biliotti; Pasquale Florio; Maria De Bonis; Felice Petraglia
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  15     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-84     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight / physiology
Female
Fetal Blood / metabolism
Gene Expression Regulation
Humans
Infant, Newborn
Obstetric Labor, Premature / blood,  metabolism*
Oxytocin / secretion
Placenta / metabolism,  physiology*
Pregnancy
RNA, Messenger / biosynthesis,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Proteins / biosynthesis*,  blood,  genetics
Chemical
Reg. No./Substance:
0/KISS1 protein, human; 0/RNA, Messenger; 0/Tumor Suppressor Proteins; 50-56-6/Oxytocin

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