Document Detail

Changes of the physiological parameters of very low-birthweight infants with chronic lung disease treated with dexamethasone.
MedLine Citation:
PMID:  11896866     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dexamethasone is widely used for the treatment of chronic lung disease (CLD), but its mechanism of action is still not clearly understood. METHODS: Respiratory status, bodyweight, blood pressure, urine volume, fluid intake and nutrient intake were investigated in 12 infants with CLD during treatment with dexamethasone. RESULTS: The mean gestational age of the patients was 26.3 +/- 2.5 weeks and their mean birthweight was 807 +/- 232 g. Treatment with dexamethasone was started at a mean age of 41 +/- 23 days. The ventilatory index (VI) improved after treatment was started. Blood pressure and urine volume increased significantly after treatment, but weight gain was poor during this time. Fluid and nutrient intake did not change before and after treatment. The degree of improvement in the VI after treatment was significantly correlated with an increase in urine volume. CONCLUSIONS: The results suggest that a rise in blood pressure as a result of dexamethasone treatment and the subsequent diuretic effect of this rise may play a role in improvement in respiratory status.
Toshio Takeuchi; Daisuke Tanaka; Noriko Saikawa; Hiroyuki Satoh; Jyunya Iwasaki; Makoto Inoue; Kenji Narui; Yoji Iikura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  44     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-05-08     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Department of Pediatrics, School of Medicine, Showa University, Shinagawa-ku, Tokyo, Japan.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Dexamethasone / therapeutic use*
Infant, Newborn
Infant, Very Low Birth Weight*
Lung Diseases / drug therapy*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone

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