| Changes of neurohumoral parameters and endothelin-1 in response to exercise in patients with mild to moderate congestive heart failure. | |
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MedLine Citation:
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PMID: 9829325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma endothelin levels are increased in patients with moderate and severe CHF. Conflicting data exist about the endothelin-1 (ET) level in patients with mild to moderate CHF and the effect of maximal exercise on plasma ET levels. METHODS AND RESULTS: We determined the plasma levels of ET and various neurohumoral parameters in 93 patients with CHF in functional class II and III of the NYHA classification at rest and after maximal bicycle exercise. Baseline ET level was increased compared to an age-matched healthy volunteer group (6.95+/-0.31 vs 3.29+/-0.17 pg/ml, mean+/-S.E.M., P<0.05), without significant differences between NYHA class II and III patients. Maximal exercise did not increase the ET level. In contrast, the neurohumoral parameters were significantly increased with maximal exercise. In conclusion, plasma levels of ET are increased in patients with mild to moderate CHF. However, no further increase in response to exercise was observed. Thus, it is highly unlikely that exercise capacity may be limited by ET-mediated peripheral vasoconstriction. |
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Authors:
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S Genth-Zotz; R J Zotz; M Cobaugh; D J van Veldhuisen; T Netzer; J Meyer; H Darius |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 66 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1999-01-21 Completed Date: 1999-01-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 137-42 Citation Subset: IM |
Affiliation:
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Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Endothelin-1 / blood* Exercise / physiology* Exercise Test Female Heart Failure / blood* Humans Male Middle Aged Neurotransmitter Agents / blood* |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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