Document Detail

Changes of myocardial high-energy phosphates with the cardiac cycle during acute or chronic myocardial stress.
MedLine Citation:
PMID:  9797156     Owner:  NLM     Status:  MEDLINE    
Whether changes of cardiac high-energy phosphate concentrations occur over the cardiac cycle remains controversial. The hypothesis was that such cyclical changes are accentuated during acute or chronic myocardial stress. Isolated rat hearts were perfused under four conditions: (1) control, (2) inotropic stimulation by doubling of perfusate [Ca2+], (3) acute hypoxia (buffer PO2 approximately 150 torr), and (4) failing, chronically infarcted hearts. 31P-MR spectra were obtained at seven time points of the cardiac cycle. Under control conditions, cyclical changes ("cycling") of ATP (11+/-3%*, *P < 0.05) and phosphocreatine (9+/-2%*) were detected, inorganic phosphate cycling did not reach statistical significance. At high [Ca2+] perfusion, cycling of phosphocreatine (9+/-5%*) was not accentuated, cycling of ATP and inorganic phosphate did not reach significance. During acute hypoxia, cycling of ATP (10+/-4%*) and inorganic phosphate (11+/-4%*) occurred, but cyclical changes of phosphocreatine were not significant. In chronically infarcted hearts, the extent of cyclical changes of ATP, phosphocreatine, and inorganic phosphate was not accentuated. Thus, in perfused rat heart, small oscillations of high-energy phosphates during the cardiac cycle are detectable, but such changes are not accentuated during acute or chronic stress. The concentrations of high-energy phosphates over the cardiac cycle are tightly regulated.
B Illing; M Horn; B Urban; H Strömer; K Schnackerz; M de Groot; A Haase; K Hu; G Ertl; S Neubauer
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  40     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-21     Completed Date:  1999-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  727-32     Citation Subset:  IM    
Medizinische Universitätsklinik, Würzburg, Germany.
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MeSH Terms
Acute Disease
Adenosine Triphosphate / metabolism*
Chronic Disease
Coronary Circulation / physiology
Disease Models, Animal
Magnetic Resonance Spectroscopy
Myocardial Infarction / diagnosis,  physiopathology*
Rats, Wistar
Reference Values
Stress, Mechanical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

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