Document Detail


Changes of muscle-derived cytokines in relation to thiol redox status and reactive oxygen and nitrogen species.
MedLine Citation:
PMID:  20533854     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of this study was to compare the levels of the plasma muscle-derived cytokines (myokines) and reactive oxygen and nitrogen species (RONS) after muscle damage triggered by different exercises, and to demonstrate the relationships between RONS, thiol redox status and myokines. Sixteen young men participated in a 90-min run at 65 % VO(2)max (Ex.1) or 90-min run at 65 % VO(2)max finished with a 15-min eccentric phase (Ex.2, downhill running). Plasma samples were collected before and at 20 min, 24 h and 48 h after exercise. The exercise trials significantly elevated the concentrations of plasma hydrogen peroxide (H(2)O(2)) and 8-isoprostane at 20 min rest. Myokines IL-6 and IL-10 increased at 20 min rest while IL-1beta and TNFalpha increased at 24 h rest following both running. Ex.2 caused a significant increase in nitric oxide (NO), IL-6, IL-10 and oxidized glutathione (GSSG) levels. Thiol redox status (GSH(total)-2GSSG/GSSG) decreased by about 30 % after Ex.2 as compared to Ex.1. H(2)O(2) and NO directly correlated with IL-6, IL-10, IL-1beta, TNFalpha and glutathione. These results show that eccentric work is an important factor that enhances the production of RONS and muscle-derived cytokines, and that there is a possible participation of thiol redox status in the release of myokines to blood.
Authors:
A Zembron-Lacny; M Naczk; M Gajewski; J Ostapiuk-Karolczuk; H Dziewiecka; A Kasperska; K Szyszka
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Publication Detail:
Type:  Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  59     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  945-51     Citation Subset:  IM    
Affiliation:
Department of Sports Medicine and Biochemistry, Faculty of Physical Culture Gorzow Wlkp., University of Physical Education Poznan, Gorzow Wlkp., Poland. agzem@gorzow.home.pl.
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