Document Detail

Changes of monoamines, purines and amino acids in rat striatum as measured by intercerebral microdialysis during ischemia/reperfusion.
MedLine Citation:
PMID:  7718861     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the time course of changes in extracellular fluid (ECF) concentrations of purines, amino acids, monoamines, and their metabolites in the striatum of rats during ischemia and reperfusion, using intracerebral microdialysis as the sampling technique. In rats subjected to 20 min forebrain ischemia by four-vessel occlusion, the concentrations of adenosine (Ade), inosine (Ino) and hypoxanthine (Hyp) were found to rise markedly. These changes were accompanied by dramatically elevated levels of aspartate (Asp), glutamate (Glu), taurine (Tau), gamma-aminobutyric acid (GABA), dopamine (DA) and norepinephrine (NE), all of which gradually returned to baseline following reperfusion. Concomitantly, the levels of metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxyindole-3-acetic acid (5-HIAA) and xanthine (Xan) decreased during ischemia and gradually recovered 60-90 min after reperfusion. It was concluded that during global brain ischemia, the ECF is flooded with both potentially harmful (e.g. Asp, Glu, DA) and protective (e.g. Tau, GABA, Ade) agents.
J Zhang; X Niu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  9     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-24     Completed Date:  1995-05-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
Institute of Materia Medica, CAMS & PUMC, Beijing.
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MeSH Terms
Amino Acids / metabolism
Biogenic Monoamines / metabolism*
Brain Ischemia / complications
Corpus Striatum / metabolism*
Extracellular Space / metabolism
Purines / metabolism
Rats, Wistar
Reperfusion Injury / etiology,  metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Monoamines; 0/Purines

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