| Changes of monoamines, purines and amino acids in rat striatum as measured by intercerebral microdialysis during ischemia/reperfusion. | |
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MedLine Citation:
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PMID: 7718861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the time course of changes in extracellular fluid (ECF) concentrations of purines, amino acids, monoamines, and their metabolites in the striatum of rats during ischemia and reperfusion, using intracerebral microdialysis as the sampling technique. In rats subjected to 20 min forebrain ischemia by four-vessel occlusion, the concentrations of adenosine (Ade), inosine (Ino) and hypoxanthine (Hyp) were found to rise markedly. These changes were accompanied by dramatically elevated levels of aspartate (Asp), glutamate (Glu), taurine (Tau), gamma-aminobutyric acid (GABA), dopamine (DA) and norepinephrine (NE), all of which gradually returned to baseline following reperfusion. Concomitantly, the levels of metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxyindole-3-acetic acid (5-HIAA) and xanthine (Xan) decreased during ischemia and gradually recovered 60-90 min after reperfusion. It was concluded that during global brain ischemia, the ECF is flooded with both potentially harmful (e.g. Asp, Glu, DA) and protective (e.g. Tau, GABA, Ade) agents. |
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Authors:
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J Zhang; X Niu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences Volume: 9 ISSN: 1001-9294 ISO Abbreviation: Chin. Med. Sci. J. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-05-24 Completed Date: 1995-05-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9112559 Medline TA: Chin Med Sci J Country: CHINA |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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Institute of Materia Medica, CAMS & PUMC, Beijing. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animals Biogenic Monoamines / metabolism* Brain Ischemia / complications Corpus Striatum / metabolism* Extracellular Space / metabolism Male Microdialysis Purines / metabolism Rats Rats, Wistar Reperfusion Injury / etiology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biogenic Monoamines; 0/Purines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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