Document Detail


Changes of the insulin-like growth factor I system during acute myocardial infarction: implications on left ventricular remodeling.
MedLine Citation:
PMID:  10323383     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro and in vivo experiments have shown important biological actions of insulin-like growth factor I (IGF-I) in heart. The aims of this study were to determine the changes in circulating IGF-I and IGF-binding proteins (IGFBPs) during acute myocardial infarction (AMI) and to explore the relationship between IGF-I levels and myocardial remodeling and function after AMI. Thirty-four patients with acute Q-wave AMI and 17 matched controls were investigated in this study. Compared to normal subjects, free IGF-I and IGFBP-3 were significantly elevated, and IGFBP-1 was decreased upon AMI. Myocardial remodeling occurred after AMI in these patients. The day 2, 3, and 7 total IGF-I levels were inversely related to day 7 left ventricular (LV) end-diastolic, end-systolic diameters (r = -0.395 to -0.516) and LV mass (r = -0.487 to -0.661). Moreover, total IGF-I levels were positively related to LV ejection fraction (r = 0.402-0.453). Compared to the healthy survivors, those patients with poor outcomes had lower total IGF-I levels immediately after AMI. Most healthy survivors had total IGF-I levels greater than 137 ng/mL, but all patients with poor outcome had total IGF-I levels less than 137 ng/mL. Thus, AMI is associated with significant alterations in the IGF-I system. A higher total IGF-I level immediately after the onset of AMI is associated with better myocardial remodeling and ventricular function.
Authors:
W L Lee; J W Chen; C T Ting; S J Lin; P H Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  84     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1575-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Veterans General Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Echocardiography, Doppler
Female
Humans
Insulin-Like Growth Factor Binding Proteins / metabolism
Insulin-Like Growth Factor I / metabolism*
Male
Middle Aged
Myocardial Infarction / pathology*,  physiopathology*
Organ Size / physiology
Survival Analysis
Ventricular Function, Left*
Ventricular Remodeling*
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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