| Changes in yearly birth prevalence rates of children with Down syndrome in the period 1986-2007 in the Netherlands. | |
| | |
MedLine Citation:
|
PMID: 21375641 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background The Netherlands are lacking reliable national empirical data in relation to the development of birth prevalence of Down syndrome. Our study aims at assessing valid national live birth prevalence rates for the period 1986-2007. Method On the basis of the annual child/adult ratio of Down syndrome diagnoses in five out of the eight Dutch cytogenetic centres, the national annual figures of the National Cytogenetic Network on total numbers of postnatal Down syndrome diagnoses were transformed into national figures on total numbers of postnatal Down syndrome diagnoses in newborn children only. In combination with the national annual data of the Working Group for Prenatal Diagnostics and Therapeutics on numbers of Down syndrome pregnancies not aborted after diagnosis, national figures on birth prevalence were constructed. Results For the period 1986-2007, results based on the data of the cytogenetic centres are almost similar to the theory-based model data of de Graaf et al., with a small discrepancy of approximately 4%. Down syndrome birth prevalence in the Netherlands shows an upward trend from around 11 per 10 000 births in the early 1990s to around 14 per 10 000 births nowadays. Conclusion In spite of expansion of antenatal screening in the Netherlands, Down syndrome live birth prevalence has risen in the last two decades as a result of rising maternal age. This increase in Down syndrome birth prevalence is in contrast to studies from other European countries. |
| | |
Authors:
|
G de Graaf; M Haveman; R Hochstenbach; J Engelen; K Gerssen-Schoorl; P Poddighe; D Smeets; G van Hove |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-6 |
Journal Detail:
|
Title: Journal of intellectual disability research : JIDR Volume: - ISSN: 1365-2788 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9206090 Medline TA: J Intellect Disabil Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. Journal of Intellectual Disability Research © 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Orthopedagogics, Ghent University, Ghent, Belgium Dutch Down Syndrome Foundation, Meppel, the Netherlands Department of Rehabilitation Sciences, University of Dortmund, Dortmund, Germany Department of Biomedical Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands Department of Clinical Genetics, Research Institute Growth and Development (GROW), Maastricht University Medical Centre, Maastricht, the Netherlands Department of Genetics, University Medical Centre Groningen, Groningen, the Netherlands Department of Clinical Genetics, Erasmus Medical Centre Rotterdam, Rotterdam, the Netherlands Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The activities and participation of adolescents with autism spectrum disorders in Singapore: finding...
Next Document: Assessment of the quality of life in families with children who have intellectual and developmental ...