Document Detail

Changes in wall viscosity and filtering as determinant of carotid and femoral atherosclerotic plaque vulnerability: theoretical analysis.
MedLine Citation:
PMID:  21096185     Owner:  NLM     Status:  MEDLINE    
Atherosclerotic plaque complication is a major cause of vascular accidents. Although a variety of factors have been proposed as key factors in these process, the mechanism that contribute to this problem remain to be characterized. Previously we demonstrated that changes in arterial wall viscous and elastic properties and/or in the filtering function (FF) could be part of the arterial wall alterations basis. If these properties are altered in arteries with atherosclerotic plaques remains to be analyzed. Our aims were 1) to analyze the arterial wall visco-elasticity and FF of carotid and femoral segments with atherosclerotic plaques, 2) to compare them with the mechanical behavior of segments without plaques (from the same artery) and of healthy arteries studied non-invasively. To this end, in each arterial segment, pressure and diameter signals were obtained, in vitro (circulation mock) and in vivo (non-invasive recordings). In atherosclerotic arteries recordings were performed on plaques and near regions without plaques. In each segment, the elasticity, the viscosity, and the wall FF were quantified. Atherosclerotic vessels, and particularly plaque regions, showed a reduced viscosity and FF. At the light of our results, hypothetical links between plaque events and changes in visco-elasticity and FF were discussed.
D Bia; J Brum; F Pessana; Y Zócalo; G Balay; C Negreira; R L Armentano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2010     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-30     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2630-3     Citation Subset:  IM    
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MeSH Terms
Atherosclerosis / pathology*
Biomechanical Phenomena
Carotid Artery, Common / pathology*
Femoral Artery / pathology*
Middle Aged
Models, Cardiovascular
Models, Statistical
Plaque, Atherosclerotic / pathology*
Signal Processing, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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