| Changes in volumetric BMD of radius and tibia upon antidepressant drug administration in young depressive patients. | |
| | |
MedLine Citation:
|
PMID: 23196265 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objectives: To determine longitudinal changes in trabecular volumetric BMD (vBMD) at tibia and radius in young depressive patients under antidepressants using pQCT. Methods: PQCT data on 26 patients (22 females, 4 males) on serotonin re-uptake inhibitors (SSRI), and 14 patients (12 females, 2 males) on non-SSRI (10 SNRI, 4 TCA) were obtained at 4% and 66% of radius and tibia at baseline and at 12-month. Depression was assessed by Beck Depression Inventory (BDI) at baseline and follow-up. Wilcoxon tests were performed to find longitudinal changes in bone parameters within each group, Mann-Whitney tests to detect differences between groups. Results: The two groups were comparable with regard to age, height and BDI. None of the measured bone parameters changed in the SSRI group. In the non-SSRI group trabecular vBMD increased slightly but significantly from baseline to follow-up at radius and tibia (p<0.03). Between group differences were significant for trabecular BMD at the radius. BDI decreased significantly in both groups by the same amount. Conclusions: Bone properties were found to be stable over 12 months under therapy with SSRIs. Whether SNRI and TCA indeed increase trabecular vBMD need to be shown in larger cohort. |
| | |
Authors:
|
L Winterhalder; P Eser; J Widmer; P M Villiger; D Aeberli |
Related Documents
:
|
6864745 - Retention of cardiopulmonary resuscitation skills by medical students. 22985205 - 12-month follow-up of fluoxetine and cognitive behavioral therapy for binge eating diso... 7482275 - Necrotizing fasciitis: an indication for hyperbaric oxygenation therapy? 9497225 - Outcome of patients with cirrhosis requiring intensive care unit support: prospective a... 15355485 - Topiramate in painful diabetic polyneuropathy: findings from three double-blind placebo... 16140225 - Are psychiatric disorders associated with worse asthma control and quality of life in a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of musculoskeletal & neuronal interactions Volume: 12 ISSN: 1108-7161 ISO Abbreviation: J Musculoskelet Neuronal Interact Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101084496 Medline TA: J Musculoskelet Neuronal Interact Country: Greece |
Other Details:
|
Languages: eng Pagination: 224-9 Citation Subset: IM |
Affiliation:
|
Department of Rheumatology and Clinical Immunology/Allergology, Inselspital Bern, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Agreement between vertical ground reaction force and ground reaction force vector in five common cli...
Next Document: Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the e...