Document Detail

Changes in ventricular septal thickness during diuretic therapy.
MedLine Citation:
PMID:  7105619     Owner:  NLM     Status:  MEDLINE    
We report on changes in echocardiographic parameters of left ventricular muscle mass in 20 hypertensive patients during short-term therapy with hydrochlorothiazide. In the group as a whole, blood pressure fell, but septal thickness and posterior wall thickness did not change. Septal thickness decreased in nine patients, and in all of these patients calculated left ventricular cross-sectional area also decreased. Septal thickness did not change or increased in 11 patients and in only one of these patients did cross-sectional area increase. These increases in septal thickness usually were associated with decreases in left ventricular transverse dimension. We therefore conclude that the increases in left ventricular wall and septal thickness during diuretic therapy probably reflect an adaptive change of cardiac muscle tissue around a smaller left ventricle.
J I Drayer; J M Gardin; M A Weber; W S Aronow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  32     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Body Weight / drug effects
Diuretics / pharmacology*
Heart Rate / drug effects
Heart Septum / drug effects*,  pathology
Heart Ventricles / drug effects
Hydrochlorothiazide / pharmacology,  therapeutic use
Hypertension / drug therapy
Middle Aged
Reg. No./Substance:
0/Diuretics; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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