Document Detail


Changes in ventricular creatine-kinase with progression and regression of cardiac hypertrophy in hypertensive rats.
MedLine Citation:
PMID:  2534419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the distribution of four isoenzymes of creatine-kinase (MM, MB, BB and the mitochondrial) in 13 renovascular hypertensive rats and five age-matched controls. After 6 weeks of hypertension, seven rats were treated with captopril (2 mg/kg daily) for 4 weeks and the other six were left untreated for 4 weeks. After the rats were killed an adaptive increase in MB and BB was found at the expense of MM in the hypertensive rats compared with the controls. The captopril-treated rats displayed persistently higher levels of both MB and BB than the controls. Therefore, the regression in cardiac hypertrophy that is achieved by captopril is accompanied by persistence of the isoenzymic pattern that leads to better use of energy-rich phosphates.
Authors:
P Pauletto; L Nascimben; D Piccolo; G Scannapieco; G Vescovo; A C Pessina; C Dal Palù
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S94-5     Citation Subset:  IM    
Affiliation:
Clinica Medica I, University of Padua, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Captopril / therapeutic use
Cardiomegaly / drug therapy,  enzymology*
Creatine Kinase / analysis*
Drug Evaluation, Preclinical
Heart Ventricles / enzymology
Hypertension, Renovascular / drug therapy,  enzymology*
Isoenzymes
Myocardium / analysis,  enzymology*
Rats
Rats, Inbred Strains
Remission Induction
Chemical
Reg. No./Substance:
0/Isoenzymes; 62571-86-2/Captopril; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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