Document Detail

Changes in uterine innervation in pregnancy and during labour.
MedLine Citation:
PMID:  20216064     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The present review highlights recent findings focusing on effects on the cervical innervation exerted by term pregnancy and labour. RECENT FINDINGS: The corpus uteri is almost denervated in term pregnancy, as demonstrated in both humans and rodents, whereas the cervical innervation remains dense throughout pregnancy and labour. In rats, fewer connections between sensory subdivisions in spinal cord segments and the cervix have been observed in late pregnancy as compared with the nonpregnant state. In term pregnancy an increased excitability of mechanosensitive afferents innervating the cervix has been demonstrated. The reasons for these seemingly contradictory findings may be clarified in further studies. Transient receptor potential vanilloid receptor, a key molecule in nociception, has been identified in the human cervix uteri in the nonpregnant state and during pregnancy and labour as opposed to the corpus, in which transient receptor potential vanilloid receptor disappears during pregnancy. These findings add evidence to the hypothesis that the uterine cervix is the main site from where labour pain propagates. SUMMARY: The conservation of the cervical innervation in term pregnancy and labour, in contrast to the corpus, and the large number of mediators involved in cervical ripening clearly indicate that the cervix plays a crucial role in pregnancy maintenance, labour initiation, labour pain and parturition.
Berith K Tingåker; Lars Irestedt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in anaesthesiology     Volume:  23     ISSN:  1473-6500     ISO Abbreviation:  Curr Opin Anaesthesiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8813436     Medline TA:  Curr Opin Anaesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-3     Citation Subset:  IM    
Division of Obstetrics and Gynecology, Department of Woman and Child Health, Stockholm, Sweden.
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MeSH Terms
Cervix Uteri / innervation,  metabolism
Estrogens / metabolism
Labor, Obstetric / metabolism*
Nerve Fibers / metabolism
Pelvis / innervation
Pregnancy / metabolism
Progesterone / metabolism
TRPV Cation Channels / metabolism
Uterus / innervation*
Reg. No./Substance:
0/Estrogens; 0/TRPV Cation Channels; 0/TRPV1 protein, human; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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