Document Detail

Changes in tumor interstitial pressure induced by photodynamic therapy.
MedLine Citation:
PMID:  1832229     Owner:  NLM     Status:  MEDLINE    
This study has examined the changes in tumor interstitial pressure exhibited during and after photodynamic therapy (PDT). The kinetics of these changes are marked by an initial decrease, followed by a rapid rise in tumor interstitial pressure. We have also employed two inhibitory agents to evaluate the different components of the pressure curve. Specially designed pressure chambers were seeded with chondrosarcoma and implanted subcutaneously in rats. Animals were injected with 0-50 mg/kg Photofrin II (i.v.) 7 days post-implantation and tumors were exposed to 0-540 J/cm2 630 nm 24 h later. Interstitial pressure was monitored via a transducer connected to the implanted chamber. Additional groups of animals were injected with either indomethacin (an inhibitor of thromboxane synthesis) or Ketanserin (a serotonin antagonist) before light treatment. Porphyrin doses of 10 mg/kg and above (135 J/cm2), or light doses of 135 J/cm2 and above (25 mg/kg Photofrin II) were effective in modifying interstitial pressure. Porphyrin doses greater than 25 mg/kg, or light doses greater than 270 J/cm2 produced no further increases in interstitial pressure. Animals given indomethacin (10 mg/kg i.p.) exhibited the initial decrease in pressure during light treatment, but showed no increase past baseline levels. Animals given Ketanserin (10 mg/kg i.p.) demonstrated no decrease in pressure during PDT, but showed the same elevations in pressure as controls. This suggests that two independent mechanisms account for the different components of the pressure curve, and that serotonin release may occur during PDT.
V H Fingar; T J Wieman; K W Doak
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  53     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-04     Completed Date:  1991-10-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  763-8     Citation Subset:  IM    
Department of Surgery, University of Louisville, KY 40292.
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MeSH Terms
Chondrosarcoma / drug therapy*,  physiopathology
Dihematoporphyrin Ether
Extracellular Space / physiology
Hematoporphyrins / therapeutic use*
Indomethacin / pharmacology
Ketanserin / pharmacology
Radiation-Sensitizing Agents / therapeutic use*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Hematoporphyrins; 0/Radiation-Sensitizing Agents; 53-86-1/Indomethacin; 74050-98-9/Ketanserin; 97067-70-4/Dihematoporphyrin Ether

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