Document Detail


Changes in tissue histamine during the estrous cycle, pregnancy and pseudopregnancy in the golden hamster.
MedLine Citation:
PMID:  4001128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The histamine content of reproductive tissues and skeletal muscle was determined in the golden hamster during the estrous cycle, pregnancy, and pseudopregnancy. Histidine decarboxylase activity was measured in uterine implantation sites and intersites from Day 4 to Day 10 of pregnancy. Histidine decarboxylase was also measured in mesometria and placentas on selected days of gestation. During the estrous cycle, uterine and skeletal muscle histamine levels were highest on Day 2 and lowest on Day 4 of the cycle. The ovarian histamine content did not change significantly among the different stages of the cycle. While the histamine content of uterine implantation sites of attachment was high on Days 4 and measurable on Days 5 and 6 of pregnancy, the levels were below the limits of detection by Day 7. On the other hand, the highest levels of histamine were in the uterine interimplantation sites on Days 8 and 9. The ovarian levels of histamine were highest on Day 13 of pregnancy. Histamine in skeletal muscle did not change significantly during pregnancy. The histidine decarboxylase activity in the implantation sites began rising on Day 9 and increased dramatically on Day 10. Placental histidine decarboxylase activity was very high on Days 13 and 15. Overall, we observed changes in uterine and skeletal muscle histamine during the estrous cycle that may be explainable in light of previously reported changes in mast cell numbers and circulating estrogens. During pregnancy, histamine levels of implantation sites and implantation intersites varied, as did the histamine content of ovarian tissue. Histidine decarboxylase activity rises in the uterus and placental tissue after the formation of the placenta.
Authors:
R J Hine; M W Orsini; L R Hegstrand
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  179     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-07-24     Completed Date:  1985-07-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cricetinae / physiology*
Estrus*
Female
Gestational Age
Histamine / metabolism*
Mesocricetus / physiology*
Muscles / metabolism
Placenta / metabolism
Pregnancy
Pregnancy, Animal*
Uterus / metabolism
Grant Support
ID/Acronym/Agency:
HD03352/HD/NICHD NIH HHS; HD12683/HD/NICHD NIH HHS; MH36787/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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