Document Detail


Changes in the testis seminiferous tubules and interstitium in prepubertal bull calves immunised against inhibin at the time of gonadotropin administration.
MedLine Citation:
PMID:  17897587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to evaluate the effects of gonadotropin administration at initiation of inhibin passive immunisation in Jersey bull calves (age 27 +/- 5 days) on testicular morphology and development. Primary treatments consisted of control (keyhole limpet haemocyanin, KLH; n = 9) or immunisation against inhibin (INH; n = 9). Subsets of calves were randomly assigned within primary treatments (TRT) to receive saline ( n = 3 per TRT), follicle-stimulating hormone (FSH; n = 3 per TRT) or gonadotrophin-releasing hormone (GnRH, n = 3 per TRT). The right testis was removed (age 118 +/- 5 days) to determine volumes of testicular components and cell numbers per testis using stereology. Data were analysed using the MIXED procedure of the SAS program. Antibody titres against inhibin were increased in INH bulls compared with KLH bulls (P < 0.05). In addition, a significant immunisation x hormone treatment interaction was noted for the number of germ cells. Administration of FSH at the time of initial immunisation against inhibin significantly increased the number of germ cells (92.2 +/- 9 x 10(6) cells) compared with INH+saline bulls (54.9 +/- 10 x 10(6) cells), with INH+GnRH bulls having an intermediate number of cells (64.5 +/- 9 x 10(6) cells; P < 0.05). These results suggest that gonadotropin administration at the time of inhibin immunisation increases the number of germ cells in the testis.
Authors:
G M Schuenemann; S M L C Mendis-Handagama; F M Hopkins; S A Kania; F N Schrick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  19     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-27     Completed Date:  2008-01-08     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  840-9     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Tennessee Agriculture Experiment Station, The University of Tennessee, Knoxville, TN 37996-4574, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / blood,  immunology*
Cattle / physiology
Follicle Stimulating Hormone / administration & dosage
Germ Cells / immunology*
Gonadotropin-Releasing Hormone / administration & dosage
Gonadotropins / administration & dosage*
Immunization
Inhibins / immunology*
Male
Seminiferous Tubules / cytology*,  immunology*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Gonadotropins; 33515-09-2/Gonadotropin-Releasing Hormone; 57285-09-3/Inhibins; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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