Document Detail


Changes in tactile stimuli-induced behavior and c-Fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush.
MedLine Citation:
PMID:  11058224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons in the superficial laminae of the dorsal horn are dominated by input from peripheral nociceptors. Following peripheral nerve injury, low threshold mechanoreceptive Abeta-fibers sprout from their normal termination site in laminae III/IV into laminae I-II and this structural reorganization may contribute to neuropathic tactile pain hypersensitivity. We have now investigated whether a sciatic nerve crush injury alters the behavioral response in rats to tactile stimuli and whether this is associated with a change in the pattern of c-Fos expression in the dorsal horn and the parabrachial area of the brainstem. Sciatic nerve crush resulted in a patchy but marked tactile allodynia manifesting first at 3 weeks and persisting for up to 52 weeks. C-Fos expression in the dorsal horn and parabrachial region was never observed on brushing the skin of the sciatic nerve territory in animals with intact nerves, but was found after sciatic nerve crush with peripheral regeneration. We conclude that after nerve injury, low threshold mechanoreceptor fibers may play a major role in producing pain-related behavior by activating normally nociceptive-specific regions of the central nervous system such as the superficial laminae of the dorsal horn and the parabrachial area.
Authors:
H Bester; S Beggs; C J Woolf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  428     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-61     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Affiliation:
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom. h.bester@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Male
Mesencephalon / metabolism
Nerve Crush / adverse effects
Nerve Regeneration / physiology
Neuronal Plasticity / physiology*
Nociceptors / cytology,  metabolism
Pain / etiology*,  pathology,  physiopathology
Peripheral Nervous System Diseases / etiology*,  pathology,  physiopathology
Physical Stimulation
Pons / metabolism
Posterior Horn Cells / metabolism*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Sprague-Dawley
Touch / physiology*
Grant Support
ID/Acronym/Agency:
NS38253-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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