| Changes in the synthesis of exportable and nonexportable proteins in parotid glands during aging. | |
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MedLine Citation:
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PMID: 7087567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The age-related differences in the synthesis of exportable and nonexportable proteins of the parotid salivary gland were compared in 2- and 24-months-old rats. Parotid slices from these rats were incubated in the presence of [14C]leucine and the amount of radioactivity incorporated into the water-soluble proteins of the postmicrosomal supernatant was compared. The exportable and nonexportable proteins were identified by electrophoretic separation of these proteins by comparing the banding patterns of the gel preparations from unstimulated glands to those from the glands stimulated to secrete. The radioactivity determination in various protein bands from these rats indicated that the synthesis of exportable secretory proteins declined with age, while that of nonexportable proteins did not appear to change. |
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Authors:
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S K Kim; D W Calkins; P A Weinhold; S S Han |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 18 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-08-26 Completed Date: 1982-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 239-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Electrophoresis, Polyacrylamide Gel Isoproterenol / pharmacology Male Parotid Gland / drug effects, metabolism* Protein Biosynthesis* Proteins / isolation & purification, secretion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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