| Changes in the surface of virus-induced cells recognized by cytotoxic T cells. I. Minimal requirements for lysis of ectromelia-infected P-815 cells. | |
| | |
MedLine Citation:
|
PMID: 178048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
P-815 mastocytoma cells developed susceptibility to immune T-cell-mediated cytolysis shortly after infection by ectromelia virus. Intracellular viral replication and late protein synthesis seem to bu unnecessary events. Interference with early protein synthesis, however, inhibits the development of susceptibility to lysis. The important intracellular events necessary for subsequent cytolysis appear to occur within 1 hour of infection. Virus rendered non-infectious by ultraviolet irradiation but not by gamma irradiation is able to induce these changes. By determining the minimum and essential events of the infectious process which result in T-cell-mediated cytolysis, the task of establishing the molecular changes occurring in the target cell surface membrane necessary for immune T-cell recognition should be simplified. |
| | |
Authors:
|
G I Ada; D C Jackson; R V Blanden; R T Hla; N A Bowern |
Related Documents
:
|
10640548 - In vitro infection of cells of the monocytic/macrophage lineage with bovine leukaemia v... 1964248 - From hela cell division to infectious diarrhoea. 9635448 - Trichomonas vaginalis: in vitro phagocytosis of lactobacilli, vaginal epithelial cells,... 22503668 - Role of chondroitin sulfate c in the action of anthrax toxin. 2174058 - Cyclic amp regulation of gs protein. thyrotropin and forskolin increase the quantity of... 20564348 - Members of the low-density lipoprotein receptor-related proteins provide a differential... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of immunology Volume: 5 ISSN: 0300-9475 ISO Abbreviation: Scand. J. Immunol. Publication Date: 1976 |
Date Detail:
|
Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 23-30 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigen-Antibody Reactions / drug effects Cell Line Cell Membrane / microbiology* Cytarabine / pharmacology Cytotoxicity Tests, Immunologic Deoxyadenosines / pharmacology Ectromelia virus / immunology Ectromelia, Infectious / immunology* Mast-Cell Sarcoma / immunology Mice Mice, Inbred BALB C Mice, Inbred CBA Poxviridae Infections / immunology* Radiation Effects T-Lymphocytes / immunology* Viral Proteins / biosynthesis Virus Replication / drug effects, radiation effects |
| Chemical | |
Reg. No./Substance:
|
0/Deoxyadenosines; 0/Viral Proteins; 147-94-4/Cytarabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transfer factor treatment of patients with multuple sclerosis. I. Preliminary report of changes in i...
Next Document: A reovirus-like agent (rotavirus) in gastroenteritis of children. Virus detection and serological st...