Document Detail

Changes in stiffness of demineralized dentin following application of collagen crosslinkers.
MedLine Citation:
PMID:  18161815     Owner:  NLM     Status:  MEDLINE    
It is thought that increasing the strength of the dentin matrix using crosslinking agents may improve both the strength and the durability of resin-dentin bonds. The purpose of this study was to evaluate the effect of two collagen crosslinking agents (glutaraldehyde, GD and grape seed extract, GSE) on the modulus of elasticity of demineralized dentin. Sound molar fragments were fully demineralized and divided into five groups according to the type and concentration of crosslinking agents: 2.5% GD; 5% GD, 25% GD; 0.65% GSE; 6.5% GSE. Specimens were immersed in their respective solution and tested at baseline, 10 min, 30 min, 1 h, 2 h, 4 h. The elastic modulus of dentin was significantly affected by the treatment (p < 0.01) and exposure time (p < 0.01). There was a statistically significant interaction between the two factors evaluated (treatment vs. time p < 0.01). Mean baselines values varied between 4.8 and 6.2 MPa in water; after 4 h of treatment the values increased between 34.9 and 242.5 MPa, that were treatment time and agent dependent. The use of these collagen crosslinkers to increase the stiffness of demineralized dentin, was both concentration and time dependent.
Ana Karina B Bedran-Russo; David H Pashley; Kelli Agee; James L Drummond; Klaus J Miescke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  86     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-16     Completed Date:  2008-09-17     Revised Date:  2012-01-13    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  330-4     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley Periodicals, Inc.
Department of Restorative Dentistry, University of Illinois at Chicago, College of Dentistry, Chicago, Illinois, USA.
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MeSH Terms
Cross-Linking Reagents / chemistry*
Dental Bonding / methods*
Dentin / chemistry*
Glutaral / chemistry
Materials Testing*
Plant Extracts / chemistry
Vitis / chemistry
Grant Support
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Plant Extracts; 111-30-8/Glutaral
Comment In:
J Esthet Restor Dent. 2011 Dec;23(6):410-6   [PMID:  22142303 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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