Document Detail

Changes in stenosis resistance and myocardial blood flow after a brief coronary occlusion in the dog.
MedLine Citation:
PMID:  6650224     Owner:  NLM     Status:  MEDLINE    
Stress-induced changes in the resistance due to coronary arterial stenosis of a fixed diameter and in the myocardial blood flow distal to the stenosis were investigated in the open-chest dog. Myocardial blood flow in the inner and outer third of the left ventricular wall was continuously measured with heated cross-thermocouples. The circumflex coronary artery was constricted with a thick string so that myocardial reactive hyperemia was nearly eliminated. Without constriction, a 15-second occlusion of the artery produced no significant changes in the resistance of large coronary arteries. On the contrary, in the presence of coronary constriction, a brief coronary occlusion caused a sustained decrease in distal coronary pressure and subendocardial myocardial flow during reactive hyperemia, while coronary flow returned quickly to the pre-occlusion level with significant reactive hyperemia of subepicardial flow. This change resulted in a long-lasting increase in the stenosis resistance. These results suggest that stenosis resistance changes dynamically, resulting in additional myocardial ischemia especially in the subendocardial myocardial layers.
D Saito; Y Abe; K Takeda; T Hyodo; H Tani; S Ohnishi; S Haraoka; H Nagashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Okayama     Volume:  37     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  423-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Coronary Circulation*
Coronary Disease / physiopathology*
Coronary Vessels
Time Factors
Vascular Resistance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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