| Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise. | |
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MedLine Citation:
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PMID: 19530223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Substantial data suggest that cognitive function can be influenced by many lifestyle activities associated with changes in energy metabolism such as exercise and diet. In the current study, we investigated the combined effects of voluntary exercise (access to running wheels) and dietary restriction (every other day fasting, EODF) on spatial memory formation and on the levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of Wistar male rats. Spatial learning and memory formation was assessed using the radial arm water maze (RAWM) paradigm, while BDNF protein was measured using ELISA test. Voluntary exercise and/or EODF were instituted for 6 weeks. Voluntary exercise alone significantly enhanced short-term, intermediate-term, and long-term memory formation, and increased BDNF protein levels in the hippocampus. EODF enhanced mean running wheel activity by approximately twofold. However, EODF did not modulate the effects of exercise on memory formation and expression of BDNF. In addition, EODF alone had no effect on memory and BDNF protein in the hippocampus. In conclusion, results of this study indicate that exercise enhanced while EODF had neutral effect on both spatial memory formation and hippocampus BDNF levels. |
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Authors:
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Omar F Khabour; Karem H Alzoubi; Mahmoud A Alomari; Mohammad A Alzubi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hippocampus Volume: 20 ISSN: 1098-1063 ISO Abbreviation: Hippocampus Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108167 Medline TA: Hippocampus Country: United States |
Other Details:
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Languages: eng Pagination: 637-45 Citation Subset: IM |
Copyright Information:
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2009 Wiley-Liss, Inc. |
Affiliation:
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Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan. khabour@just.edu.jo |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain-Derived Neurotrophic Factor / metabolism* Enzyme-Linked Immunosorbent Assay / methods Food Deprivation / physiology* Gene Expression Regulation / physiology Hippocampus / metabolism* Male Maze Learning / physiology Memory / physiology* Physical Conditioning, Animal / physiology* Random Allocation Rats Rats, Wistar Space Perception / physiology* Statistics, Nonparametric Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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