Document Detail

Changes in some ultrastructural parameters of cortical synapses in the initial phases of kindling.
MedLine Citation:
PMID:  6484027     Owner:  NLM     Status:  MEDLINE    
Repeated electrical stimulation of the sensorimotor region of rat cerebral cortex at 10 min intervals led to the development and progressive prolongation of self-sustained after-discharges (SSAD). One minute after the third SSAD ended, an electronoptic morphological analysis of type I synapses after Gray from the second cortical layer of the homotopic area of the unstimulated hemisphere was carried out. In the experimental animals, an 11.7% increase in the area of the presynaptic bag and a 5.5% increase in its perimeter were demonstrated. The number of agranular synaptic vesicles per constant unit area fell by 70.8%. The area of the mitochondria in the presynaptic ending increased by 49.8% and their perimeter by 16.1%. The area of the postsynaptic element increased by 34.1% and its perimeter by 15.7%. Changes in the synapses are evaluated as manifestations of exhaustion and primarily as a manifestation of ion shifts during the epileptic seizure. The findings nevertheless also testify to incipient activation of restitution mechanisms in the structures of the synaptic apparatus within a very short time after termination of the seizure.
M Langmeier; J Mares
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologia Bohemoslovaca     Volume:  33     ISSN:  0369-9463     ISO Abbreviation:  Physiol Bohemoslov     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-20     Completed Date:  1984-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0175317     Medline TA:  Physiol Bohemoslov     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  367-75     Citation Subset:  IM    
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MeSH Terms
Cerebral Cortex / physiology,  ultrastructure*
Electric Stimulation
Kindling, Neurologic*
Microscopy, Electron
Rats, Inbred Strains
Synapses / physiology,  ultrastructure*

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