Document Detail

Changes in somatostatin-like activity in discrete areas of the rat hypothalamus during different stages of proestrus and diestrus and their relation to serum gonadotropin, prolactin, and growth hormone levels.
MedLine Citation:
PMID:  6403329     Owner:  NLM     Status:  MEDLINE    
To investigate physiological changes in the somatotropin release-inhibiting factor (SRIF) content of the hypothalamus during the estrous cycle, groups of 8-10 rats were decapitated every 2 h from 0800-1800 h on proestrus and diestrus. SRIF was assayed in the preoptic suprachiasmatic area, posterior hypothalamus, arcuate nucleus area, and median eminence. Gonadotropins, PRL, and GH were measured in trunk blood and correlated with concentrations of SRIF. A marked decrease in SRIF occurred between 0800-1400 h of proestrus in the preoptic suprachiasmatic area (1.00 +/- 0.28 vs. 0.09 +/- 0.03 micrograms/g wet wt, P less than 0.001) and the posterior hypothalamus (0.43 +/- 0.10 vs. 0.02 +/- 0.004 micrograms/g, P less than 0.001). A similar pattern of decrease in SRIF also occurred in the tissue containing the arcuate nucleus (2.09 +/- 0.37 vs. 0.98 +/- 0.13 micrograms/g, P less than 0.01). In the median eminence the lowest SRIF concentration was measured at 1600 h (31.4 +/- 3.4 vs. 22.0 +/- 1.32 micrograms/g, P less than 0.02). Diestrous values for SRIF did not change in the posterior hypothalamus and arcuate area; however, values increased slightly in the median eminence and decreased in the preoptic suprachiasmatic area between 1400-1800 h. Spearman's correlation coefficient (rs) between PRL and SRIF in the preoptic suprachiasmatic area and the posterior hypothalamus was rs = -0.66 and rs = -0.55 (P less than 0.001), respectively.
U A Knuth; G S Sikand; F F Casanueva; H G Friesen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  112     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1506-11     Citation Subset:  AIM; IM    
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MeSH Terms
Follicle Stimulating Hormone / blood
Gonadotropins / blood*
Growth Hormone / blood*
Hypothalamus / metabolism*
Luteinizing Hormone / blood
Peptides / metabolism*
Prolactin / blood*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Gonadotropins; 0/Peptides; 0/somatostatin-like peptides; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-72-6/Growth Hormone

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