Document Detail

Changes in soluble interleukin-2 receptor level in serum and Na+-K+-exchanging ATPase activity in semen of infertile men caused by antisperm antibody.
MedLine Citation:
PMID:  11232795     Owner:  NLM     Status:  MEDLINE    
AIM: To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb). METHODS: The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na+-K+-exchanging ATPase activity in semen by phosphorus (Pi) assay. RESULTS: The sIL-2R level in serum was significantly higher and the Na+K+-exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls. CONCLUSION: The AsAb titer varies with the sIL-2R level in serum. A decrease in Na+-K+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb.
J Ni; Q L Li; W Zhang; J S Xie; S L Bian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian journal of andrology     Volume:  2     ISSN:  1008-682X     ISO Abbreviation:  Asian J. Androl.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2001-03-05     Completed Date:  2001-05-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100942132     Medline TA:  Asian J Androl     Country:  China    
Other Details:
Languages:  eng     Pagination:  151-3     Citation Subset:  IM    
Department of Physiology, Harbin Medical University, China.
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MeSH Terms
Autoantibodies / immunology*
Infertility, Male / immunology*,  metabolism*
Receptors, Interleukin-2 / blood*
Semen / enzymology*
Sodium-Potassium-Exchanging ATPase / metabolism*
Spermatozoa / enzymology*,  immunology*
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, Interleukin-2; EC ATPase

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