Document Detail

Changes in socio-emotional behavior under imipramine treatment in normal and amygdalo-hypothalamic dogs.
MedLine Citation:
PMID:  3788669     Owner:  NLM     Status:  MEDLINE    
The effects of imipramine on learned social responses were examined in ten dogs with dorsomedial amygdalar lesions and/or lateral hypothalamic lesions. Six of the ten dogs were also tested preoperatively. The social responses were instrumentally conditioned using social interaction with the experimenter as reinforcement (petting and verbal reassurance). In the non-lesioned dogs imipramine treatment produced a dose-dependent deterioration of performance during drug administration followed by a long-term amelioration of performance. In the lesioned dogs imipramine produced various changes in performance depending on the pretreatment level of responding. When the pretreatment level of performance was high drug administration resulted in a long-term deterioration, and when performance was poor imipramine produced a continuous and long-term increase. It is suggested that imipramine facilitates the recovery of performance, but suppresses well-performed responses.
E Kostarczyk; E Fonberg; J C Prechtl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  46     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-06     Completed Date:  1987-01-06     Revised Date:  2011-01-07    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  187-203     Citation Subset:  IM    
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MeSH Terms
Amygdala / physiology*
Depression / drug therapy*
Disease Models, Animal
Emotions / drug effects
Hypothalamic Area, Lateral / physiology*
Imipramine / pharmacology*
Motor Activity / drug effects
Social Behavior*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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