Document Detail

Changes in smell acuity induced by radiation exposure of the olfactory mucosa.
MedLine Citation:
PMID:  3390326     Owner:  NLM     Status:  MEDLINE    
The effects of ionizing radiation on smell acuity were assessed in 12 patients in whom the olfactory mucosa was exposed to radiation in the course of treatment for nasopharyngeal carcinoma or pituitary adenoma. Olfactory detection thresholds for two odorants (amyl acetate and eugenol) were determined before the start of radiation therapy, within a week of termination of therapy, and 1, 3, and 6 months later. The results show clearly that smell acuity is profoundly affected by therapeutic irradiation. Thresholds had increased in all 12 patients by the end of treatment and were still high one month later. Varying degrees of recovery were noted in most patients three to six months after cessation of treatment. The fate of the sense of smell deserves more attention when considering the disability caused by irradiation to certain head and neck tumors.
D Ophir; A Guterman; R Gross-Isseroff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  114     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-08-24     Completed Date:  1988-08-24     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  853-5     Citation Subset:  AIM; IM    
Department of Otolaryngology, Kaplan Hospital, Rehovot, Israel.
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MeSH Terms
Nasal Mucosa / radiation effects*
Smell / radiation effects*

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