Document Detail


Changes in small vessel blood content of the rat heart induced by hypercapnic, hyperoxic or asphyxic conditions.
MedLine Citation:
PMID:  26467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The small vessel blood content (SVBC) of the ventricular walls of the heart of anesthetized closed chest rats was determined using 59FeC13 to label the plasma siderophilin. SVBC was measured breathing air, 100% O2, 5% CO2 in 21% O2 and during asphyxia. The average SVBC could be ranked: air less than 100% O2 less than 5% CO2 less than asphyxia. Only the '100% O2' values were not significantly above the 'air' values. Under control conditions, SVBC of the rat heart averaged 6.77 +/-(SE) 0.23 ml blood/100 g tissue. Inhalation of 5% CO2 increased this to 8.68 +/- 0.34, while asphyxia produced a maximal response to 14.40 +/- 0.77. Comparison of SVBC were made between various regions of the ventricular walls. The only significant difference was that the right side of the septum had a lower SVBC than the left ventricular subepicardium under all conditions except CO2. These differences in SVBC are related to the number of open capillaries in the myocardium. Thus inhalation of CO2 decreases intercapillary distance while 100% O2 has no effect.
Authors:
H R Weiss; J A Cohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  63     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1978  
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  199-207     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Asphyxia / physiopathology*
Coronary Circulation*
Hydrogen-Ion Concentration
Hypercapnia / physiopathology*
Microcirculation
Oxygen / blood*
Partial Pressure
Rats
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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