Document Detail

Changes in signalling molecule levels in 10-day hindlimb immobilized rat muscles.
MedLine Citation:
PMID:  15676058     Owner:  NLM     Status:  MEDLINE    
AIM: Hindlimb immobilization produces similar percentage decreases in muscle mass in the predominantly type I soleus and type II vastus lateralis muscles. Consequently we hypothesized that the percentage changes in potential regulatory molecules for atrophy would be similar in the two muscle fibre types. METHODS: Therefore, the purpose of the current study was to measure phosphorylated p38 MAPK and JNK, as well as the protein levels of p53, growth arrest and DNA damage-inducible 45 (GADD45), and full-length poly(ADP-ribose) polymerase (PARP) to determine whether their changes in expression in the soleus and vastus lateralis muscles were similar at 10th day of hindlimb immobilization in young rats. RESULTS: Unexpectedly, preferential increases in phosphorylation of p38 MAPK and JNK and in the protein levels of p53, GADD45, as well as decreases in full-length PARP occurred in the soleus muscle, while only p38 phosphorylation increased in the white portion of the vastus lateralis muscle at 10th day of hindlimb immobilization. CONCLUSION: Taken together, these results are interpreted to suggest that some of regulatory processes or kinetics in the atrophy of type I and II muscle fibres during limb immobilization may differ at the 10th day of limb immobilization.
S Machida; F W Booth
Related Documents :
12432448 - Nitric oxide synthase ii in rat skeletal muscles.
6538128 - The relative isometric strength of type i and type ii muscle fibres in the human quadri...
8953748 - Distribution of muscle fibre types in the thoracic and lumbar epaxial muscles of japane...
8676058 - Gh regulation of the type 2 igf receptor in regenerating skeletal muscle of rats.
24371018 - Mature igf-i excels in promoting functional muscle recovery from disuse atrophy compare...
22806378 - Nerve ultrasound follow-up in a child with guillain-barré syndrome.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  183     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-28     Completed Date:  2005-03-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
DNA Damage
Intracellular Signaling Peptides and Proteins
JNK Mitogen-Activated Protein Kinases / analysis
Mitogen-Activated Protein Kinases / analysis*
Muscle Proteins / analysis*
Muscle, Skeletal / chemistry*,  enzymology,  growth & development
Muscular Atrophy / metabolism
Poly(ADP-ribose) Polymerases / analysis
Proteins / analysis
Rats, Inbred F344
Tumor Suppressor Protein p53 / analysis
p38 Mitogen-Activated Protein Kinases / analysis
Grant Support
Reg. No./Substance:
0/GADD45 protein; 0/Intracellular Signaling Peptides and Proteins; 0/Muscle Proteins; 0/Proteins; 0/Tumor Suppressor Protein p53; EC Polymerases; EC Mitogen-Activated Protein Kinases; EC Protein Kinases; EC Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endothelin-1-induced proliferation of human endothelial cells depends on activation of K+ channels a...
Next Document:  Elevations in core and muscle temperature impairs repeated sprint performance.