Document Detail


Changes in serum and urinary uric acid levels in normal human subjects fed purine-rich foods containing different amounts of adenine and hypoxanthine.
MedLine Citation:
PMID:  1619189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of ingesting some purine-rich foods (beef liver, haddock fillets and soybeans) on uric acid metabolism was investigated in 18 male subjects with no history of gout or kidney disorder. In a crossover design, three isoenergetic and isonitrogenous meals were fed to volunteers during a 3-week period. Only the content of uricogenic bases (adenine and hypoxanthine) varied among the test meals. Ingestion of all experimental meals caused an increase in serum uric acid levels at 120 minutes and this increase was more marked (about twofold) with haddock and soybean ingestion. In all groups, the postprandial serum uric acid levels at 240 minutes were lower than those obtained at 120 minutes, but still remained elevated in comparison to the fasting level. The test foods had little or no effect on serum and urinary creatinine values. As expected, 24-hour urinary uric acid excretion was similar for the three test meals due to the isonitrogenous load of proteins and purines. Assessment of each purine base content rather than the total purine content of foods should be considered in future recommendations for hyperuricemic individuals.
Authors:
D Brulé; G Sarwar; L Savoie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  11     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-03     Completed Date:  1992-08-03     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  353-8     Citation Subset:  IM    
Affiliation:
Bureau of Nutritional Sciences, Food Directorate, Health Protection Branch, Banting Research Centre, Ottawa, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adenine / analysis*
Adult
Diet*
Food Analysis
Humans
Hypoxanthine
Hypoxanthines / analysis*
Liver / chemistry
Male
Middle Aged
Purines / pharmacology*
Soybeans / chemistry
Uric Acid / blood,  metabolism*,  urine
Chemical
Reg. No./Substance:
0/Hypoxanthines; 0/Purines; 120-73-0/purine; 68-94-0/Hypoxanthine; 69-93-2/Uric Acid; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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