Document Detail

Changes in serum markers of oxidative stress with varying periods of haemodialysis.
MedLine Citation:
PMID:  15056266     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Oxidative stress possibly helps promote the progression and complications of chronic renal failure (CRF). Haemodialysis (HD) may aggravate oxidative stress. This controlled, cross-sectional clinical study with blind outcome assessment evaluated the effect of prolonged HD treatment on oxidative stress. METHODS AND RESULTS: Seventy patients (M/F = 33/37) with CRF and who were on HD were divided into six groups with differing treatment periods of HD; from 3 to 12 months to 85-120 months. Twelve healthy subjects acted as controls. The serum levels of thiobarbituric acid reactive substances (TBARS), total sulfhydryl (SH) groups and protein carbonyls (PCs) were determined. Compared with controls, PCs were increased in patients, and this positively correlated with the duration of HD. Treatment for more than 24 months caused the most striking increases in PCs, with relevant differences as compared to those on HD for a maximum of 12 months. Increasing periods of HD were associated with increases in TBARS and similar decreases in SH as compared with controls; the differences between the SH levels of those on HD for more than 84 months and those on HD for up to 24 months were significant. CONCLUSION: Our results indicate that HD continued for more than 2 years aggravates the latter. Decreased potential for oxygen-radical-scavenger activity becomes pronounced after 7 years of HD treatment.
Tülay Köken; Mustafa Serteser; Ahmet Kahraman; Cigdem Gökçe; Serap Demir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  9     ISSN:  1320-5358     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Biochemistry and Clinical Biochemistry, Division of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
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MeSH Terms
Biological Markers
Middle Aged
Oxidative Stress*
Renal Dialysis*
Sulfhydryl Compounds / blood
Thiobarbiturates / blood
Reg. No./Substance:
0/Biological Markers; 0/Sulfhydryl Compounds; 0/Thiobarbiturates; 504-17-6/thiobarbituric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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